Interested Sites
Information for Interested Sites
View information for sites interested in participating in the THRIVE study, including requirements and enrollment criteria.
Thank you for your interest in learning more about becoming a THRIVE enrollment site. Enrollment sites will be selected through a comprehensive review process that considers several key factors, including the strength and reliability of existing research infrastructure, demonstrated institutional commitment to clinical trials, diversity and characteristics of the patient population, and the breadth of surgical procedures performed at the site. In addition, participating centers must have experience and comfort administering both propofol total intravenous anesthesia (TIVA) and inhaled volatile anesthetics, as both modalities are essential to the THRIVE study design.
As you consider participation, please note that patients must meet specific inclusion and exclusion criteria in order to enroll in the THRIVE trial. These criteria ensure that the study population is appropriate for the research objectives and that patient safety remains paramount. Detailed eligibility requirements for patient participation are provided below.
Inclusion Criteria
Each patient must meet all the following criteria:
- Aged 18 years or older
- Undergoing elective non-cardiac surgery expected to last ≥ 60 min requiring general anesthesia with a tracheal tube or laryngeal mask airway (or similar supra-glottic device)
Exclusion Criteria
Patients will not be enrolled if any of the following criteria are met:
- Inability to provide informed consent in English
- Pregnancy (based on patient report or positive test on the day of surgery)
- Surgical procedure requiring general, regional, neuraxial anesthesia administered by an anesthesia clinician (anesthesiologist, CRNA, anesthesiology assistant) occurring within 30 days prior to or planned to occur within 30 days after surgery date
- Contraindication to propofol TIVA or inhaled volatile (for example, documented allergy to propofol, history of severe postoperative nausea or vomiting, concern for or history of malignant hyperthermia) based on self report
- Surgical procedures requiring a specific general anesthesia technique (for example, TIVA required for neuromonitoring).
- Local institutional, written protocol mandating a specific general anesthesia technique
- History of intraoperative awareness during general anesthesia based on patient self-report
- Planned postoperative intubation