Information For Interested Sites

Thank you for your interest in learning more about becoming a THRIVE enrollment site. Enrollment sites will be selected based on a number of criteria, including research infrastructure, institutional commitment, patient demographics, types of surgeries performed, and comfort with both types of anesthesia (propofol TIVA and inhaled volatile anesthesia). 

Please note that in order to enroll in the THRIVE trial, patients need to meet certain inclusion and exclusion criteria. Criteria for patient participation can be found below.

Inclusion Criteria
Each patient must meet all the following criteria:

  • Aged 18 years or older
  • Undergoing elective non-cardiac surgery expected to last ≥ 60 min requiring general anesthesia with a tracheal tube or laryngeal mask airway (or similar supra-glottic device)

Exclusion Criteria
Patients will not be enrolled if any of the following criteria are met:

  • Inability to provide informed consent in English
  • Pregnancy (based on patient report or positive test on the day of surgery)
  • Surgical procedure requiring general, regional, neuraxial anesthesia administered by an anesthesia clinician (anesthesiologist, CRNA, anesthesiology assistant) occurring within 30 days prior to or planned to occur within 30 days after surgery date
  • Contraindication to propofol TIVA or inhaled volatile (for example, documented allergy to propofol, history of severe postoperative nausea or vomiting, concern for or history of malignant hyperthermia) based on self report
  • Surgical procedures requiring a specific general anesthesia technique (for example, TIVA required for neuromonitoring).
  • Local institutional, written protocol mandating a specific general anesthesia technique
  • History of intraoperative awareness during general anesthesia based on patient self-report
  • Planned postoperative intubation
For any inquiries please email
askthrive@umich.edu