The Multicenter Perioperative Outcomes Group (MPOG), Association of University Anesthesiologists (AUA), and Department of Anesthesiology at the University of Michigan are delighted to announce a three-year, $950,000 funding opportunity to support a multicenter pragmatic clinical trial in perioperative anesthesiology. The trial should be designed to answer a compelling clinical question around which clinical equipoise exists and can be ethically addressed without individual patient consent.  

The award will be made to a single clinical coordinating center (CCC) that is an MPOG active member. The MPOG Data Coordinating Center (DCC) at the University of Michigan will act as the trial DCC. In addition to direct financial support from IMPACT ($700,000) for the CCC and performance sites, MPOG will provide support in-kind ($250,000) as the DCC with technical, clinical informatics, and statistical support. 

The award will be made in a phased manner with a Year 1 Feasibility Phase ($100,000) and milestone-based progression to Years 2-3 Full Scale Phase ($300,000 per year).  

Interested applicants with faculty appointments at active MPOG center(s) should provide a 2-page Letter of Intent (LOI), from which applications will be selected to provide full proposals. An optional informational webinar and Q&A for interested applicants will be held on Aug 18, 2023 from 1-2pm EST to address questions which may arise about the application process, programmatic goals, or feasible approaches. 

Frequently asked questions related to the IMPACT initiative can be found here.

The deadline for LOI submissions will be 8pm ET on September 22nd.  Subsequently invited full proposals will be reviewed by external Subject Matter Expert (SME) reviewers in a manner consistent with NIH guidelines.