Call For Letters of Intent:
Initiative for Multicenter Pragmatic
Anesthesiology Clinical Trials (IMPACT)

The Multicenter Perioperative Outcomes Group (MPOG), Association of University Anesthesiologists (AUA), and Department of Anesthesiology at the University of Michigan are delighted to announce a three-year, $950,000 funding opportunity to support a multicenter pragmatic clinical trial in perioperative anesthesiology. The trial should be designed to answer a compelling clinical question around which clinical equipoise exists and can be ethically addressed without individual patient consent 

The award will be made to a single clinical coordinating center (CCC) that is an MPOG active member. The MPOG Data Coordinating Center (DCC) at the University of Michigan will act as the trial DCC. In addition to direct financial support from IMPACT ($700,000) for the CCC and performance sites, MPOG will provide support in-kind ($250,000) as the DCC with technical, clinical informatics, and statistical support. 

The award will be made in a phased manner with a Year 1 Feasibility Phase ($100,000) and milestone-based progression to Years 2-3 Full Scale Phase ($300,000 per year).  

Interested applicants with faculty appointments at active MPOG center(s) should provide a 2-page Letter of Intent (LOI), from which applications will be selected to provide full proposals. An optional informational webinar and Q&A for interested applicants will be held on Aug 18, 2023 from 1-2pm EST to address questions which may arise about the application process, programmatic goals, or feasible approaches. 

Frequently asked questions related to the IMPACT initiative can be found here.

The deadline for LOI submissions will be 8pm ET on September 22nd.  Subsequently invited full proposals will be reviewed by external Subject Matter Expert (SME) reviewers in a manner consistent with NIH guidelines.

Key Dates:

Aug 18, 2023 Optional informational webinar and Q&A (will be recorded)
Sep 22, 2023
Mandatory 2-page Letter of Intent (LOI) submitted by 8pm ET
Sep 27, 2023 – LOI scoring opens
Oct 6, 2023 – LOI scoring closes 8pm ET
Oct 16, 2023 – MPOG Executive Board Invites approximately 5-8 LOIs for solicitation of full proposal
Dec 15, 2023 – Final full proposals submitted to MPOG Coordinating Center by 8pm EST
Feb 2, 2024 – Up to three finalists contacted, summary statements released, additional info requested
Feb 23, 2024 – Additional information response window closes at 8pm ET
Mar 8, 2024 – MPOG Executive Board endorses winning proposal 
July 1, 2024 – Year 1 Feasibility Phase Start
May 1, 2025 – MPOG Executive Board reaches decision on suitability for progression to Full-Scale Phase
July 1, 2025 – Year 2 Full Scale Phase Start (if approved)

For any inquiries please email