
History
•Treatment paradigms ‘borrowed’ from large critical care randomized control trials: most
recently NICE-SUGAR (2009)
•Target BG<180 mg/dL associated with lower ICU mortality compared with
aggressive target BG 81-108 mg/dL
•Studies of some groups (cardiac surgical, vascular, complex hepatobiliary, thoracic,
others) have suggested optimal target of 80-110 mg/dL, <150 mg/dL, and other
regimens.
•Several smaller studies of perioperative patients have reinforced BG target 80-180 mg/dL
to reduce risk of hyperglycemic complications in all groups, and target BG 140-180
mg/dL likely the optimal range to combine benefit with reduced risk of hypoglycemic
events
•Mirror recommendations from national societies (ADA, Endocrine Society, SCCM);
ambulatory recommendations more relaxed (SAMBA)