
Previously, anbiocs were administered aer umbilical cord clamping due to concerns about fetal exposure.
Subsequent studies found no increased incidence of fetal complicaons, and established that peak plasma
anbioc concentraon should occur at the me of surgical incision to reduce infecon risk.
Prophylacc anbioc administraon before incision is strongly supported by both ACOG and the American
Academy of Pediatrics, which affirms that fetal exposure is acceptable.
To summarize: this measure captures the percentage of cesarean deliveries with documented anbiocs within
one hour, with leniency for vancomycin (consistent with standard OR cases). Inclusion criteria are cesarean
deliveries and cesarean hysterectomy cases, as both require surgical site infecon prophylaxis. Exclusions include
non-obstetric cases, neuroaxial analgesia cases that do not progress to cesarean (related to OB anesthesia
phenotype coding in MPOG), and paents on scheduled anbiocs within approximately 4 hours prior.
The measurement window differs for non-emergent versus emergent cases. For non-emergent cases, anbiocs
must be documented up to the me of incision. For emergent cases, leniency is allowed — anbiocs may be given
at any point during the OR visit, up to anesthesia end. This is a MOCA measure available for provider feedback,
with a success threshold of 90%.
Current performance is strong — the vast majority of instuons are meeng the 90% threshold. Here is how I
structured the review analysis. On clinical appropriateness: yes, this measure is clinically relevant. Postpartum
infecons are a significant cause of morbidity, appropriate prophylaxis reduces infecon frequency, and anbiocs
should be given before incision to achieve peak plasma concentraon at the me of incision. I recommend keeping
this measure. On inclusion and exclusion criteria: the current criteria are appropriate — including cesarean
deliveries and cesarean hysterectomies, and excluding paents already on scheduled anbiocs. At our instuon
we sll administer SSI prophylaxis in those cases, but some instuons exclude them, and that’s accounted for. I
recommend no changes to inclusion or exclusion criteria. Regarding success criteria and flagged cases:
I believe the current approach is appropriate. Vancomycin leniency is reasonable, and consistent with prior
decisions, leniency for emergent cases — extending the window to anesthesia end — is also reasonable. A
literature search found no evidence of benefit to administering anbiocs earlier versus later aer incision, so if we
allow a few minutes post-incision, there is no clear reason to restrict it to less than 30 minutes aer.
The next queson is whether to adjust criteria for paents with high BMI or weight. Some studies use thresholds of
110–120 kg or BMI over 40. This is relevant given increasing obesity prevalence on labor floors. However, based on
my review, I do not recommend a change.
At our instuon, we do give a higher dosage for paents over 110 kg, but this does not appear to be supported in
the literature. For this measure, surgical site infecon primarily refers to skin infecons — endometris is
addressed separately by azithromycin (anbioc measure 06). The primary organisms of concern are MSSA, MRSA,
and gram-negaves such as E. coli and Klebsiella. For these organisms, the 2-gram dosage achieves appropriate
minimum inhibitory concentraons. Mulple studies found that re-dosing within 2 hours is sufficient. For cases
extending beyond 2 hours, blood loss of 1,500 mL typically triggers re-dosing anyway, making dose adjustment for
weight a moot point. Recommendaon: no dosage adjustment for higher-weight paents.
The next topic is second-line agents, which we encounter frequently due to documented penicillin allergies —
oen inappropriately documented. The standard recommendaon is clindamycin plus an aminoglycoside,